Hydrochloric Acid → HCID 86680947, compound

HRID 2365454Notes

Reaction equation

HRID 2365454 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:39]=[CH:38][C:9]([CH2:10][NH:11][C:12]2[CH:17]=[C:16]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[N:15]=[C:14]([NH:24][C:25]3[CH:37]=[CH:36][C:28]([C:29]([O:31]C(C)(C)C)=[O:30])=[CH:27][CH:26]=3)[N:13]=2)=[CH:8][CH:7]=1.Cl>O1CCOCC1>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:10][NH:11][C:12]2[CH:17]=[C:16]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[N:15]=[C:14]([NH:24][C:25]3[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:36][CH:37]=3)[N:13]=2)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680948HCID 86680948, compound

Product 1

HCID 86680947HCID 86680947, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl 4-((4-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-2-yl)amino)benzoate (34 mg, 0.06 mmol) and 4 N HCl in dioxane (1 mL) were stirred for 8 hs then concentrated under vacuum to give 4-((4-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-2-yl)amino)benzoic acid (31 mg, 0.06 mmol) which was carried to the next step without purification.

Workup

  1. concentrationthen concentrated under vacuum

Sources & evidence

ORD record
ord-446c8c950cb6412fa96f67fc9e5b2444
Source dataset
uspto-grants-2014_04
Patent number
US08697706B2

Reaction notes

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