Hydrogen Bromide → HCID 20216114, compound

HRID 236553Notes

Reaction equation

HRID 236553 reaction equation
[BrH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1>CC(C)=O>[BrH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:9][CH:10]=[CH:11][CH2:12][CH2:13]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 202160941-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine

Product 1

HCID 20216114HCID 20216114, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Aqueous hydrobromic acid (48% w/w) was added dropwise, with stirring, to a solution of 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine (4.0 g.) in acetone (50 ml.) until no further precipitate was obtained. The solid was collected by filtration and recrystallised from ethanol to give 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrobromide (Example 18) (2.9 g.), m.p. 187°-190° C.

Workup

  1. customwas obtained
  2. filtrationThe solid was collected by filtration
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-03b8b3cfebe4412193a49d5ec1eff538
Source dataset
uspto-grants-1987_02
Patent number
US04645771

Reaction notes

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