反应详情

To a Grignard reactant prepared from 2.2 g. of magnesium turnings and 23.4 g. of 4-[2-(dimethylamino)-ethoxy]-bromobenzene in 100 ml. of dry tetrahydrofurane a solution of 10 g. of m-chloro-propiophenone in 30 ml. of tetrahydrofurane is added dropwise, at 20° C. The reaction mixture is stirred at room temperature for another two hours, cooled, and filtered onto a 20% aqueous ammonium chloride solution. Tetrahydrofurane is distilled off in vacuo. The residue is extracted with ether, the ethereal phase is washed with water, dried over anhydrous magnesium sulfate, filtered, and ether is distilled off. Crystallization of the residue from a mixture of n-hexane and ethyl acetate yields 14.2 g. of the named compound, melting at 108° to 109° C.

1. temperaturecooled
2. filtrationfiltered onto a 20% aqueous ammonium chloride solution
3. distillationTetrahydrofurane is distilled off in vacuo
4. extractionThe residue is extracted with ether
5. washthe ethereal phase is washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. distillationether is distilled off
9. customCrystallization of the residue
10. additionfrom a mixture of n-hexane and ethyl acetate
11. customyields 14.2 g