HCID 25193405, compound → 934162-32-0

HRID 2366460Notes

Reaction equation

HRID 2366460 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][C:8]([F:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]>C1COCC1.C(O)C.[Ni]>[NH2:1][C:2]1[C:10]([NH2:11])=[CH:9][C:8]([F:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Participants

5

Reactant 1

HCID 25193405HCID 25193405, compound

Product 1

HCID 25194665934162-32-0

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of EXAMPLE 45C (11.2 g) in a mixture of THF (50 mL) and ethanol (50 mL) was added Raney nickel (50% in water, 11.0 g). The mixture was stirred under hydrogen (60 psi) for 5 hours. Solid material was filtered off and the filtrate was concentrated.

Workup

  1. filtrationSolid material was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-61ea365c9aeb475584ace8a60f91860c
Source dataset
uspto-grants-2014_04
Patent number
US08697736B2

Reaction notes

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