N-methyl-2-pyrrolidone → HCID 68852559, compound

HRID 2366524Notes

Reaction equation

HRID 2366524 reaction equation
Br[C:2]1[C:3]([CH3:12])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[CH3:13][N:14]1CCCC1=O>[C-]#N.[Zn+2].[C-]#N.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:13]([C:2]1[C:3]([CH3:12])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2)#[N:14]

Participants

5

Reactant 2

HCID 13387N-methyl-2-pyrrolidoneHCID 134194458-Bromo-7-methylquinoline

Product 1

HCID 68852559HCID 68852559, compound

Reagents, catalysts & solvents 2

HCID 11186Zinc cyanide (Zn(CN)2)CatalystHCID 178418397HCID 178418397, compoundCatalyst

Procedure

Prepared by reacting 8-bromo-7-methyl-quinoline with zinc cyanide in the presence of tetrakis(triphenylphosphine)palladium in N-methylpyrrolidinone under a protective gas atmosphere at 100-105° C.

Workup

  1. customPrepared
  2. customat 100-105° C.

Sources & evidence

ORD record
ord-71e23dfc06254266b66a8ce99ad335fd
Source dataset
uspto-grants-2014_04
Patent number
US08697868B2

Reaction notes

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