HCID 69506827, compound → HCID 57457840, compound

HRID 2366735Notes

Reaction equation

HRID 2366735 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]1([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:19][CH2:18][CH2:17]1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>[Pt]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]1([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:19][CH2:18][CH2:17]1)=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

3

Reactant 1

HCID 69506827HCID 69506827, compound

Product 1

HCID 57457840HCID 57457840, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

The method described in Part D of Example 64 was used to hydrogenate (35 psi, 2.4×105 Pa) ethyl 1-{[(3-nitroquinolin-4-yl)amino]methyl}cyclobutanecarboxylate (10.0 g, 30.4 mmol) in the presence of 5% platinum on carbon (1.0 g) to provide ethyl 1-{[(3-aminoquinolin-4-yl)amino]methyl}cyclobutanecarboxylate as a yellow solid.

Sources & evidence

ORD record
ord-e6447617a5954461be238b76ae71e464
Source dataset
uspto-grants-2014_04
Patent number
US08697873B2

Reaction notes

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