Diethylamine → N,N-DIETHYL-1-METHYL-PIPERIDINE-4-CARBOXAMIDE

HRID 2366816Notes

Reaction equation

FC1C=C(F)C=C(F)C=1C(NC1C=CC=C([C:13]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[O:14])N=1)=O.C[N:29]1[CH2:34][CH2:33]C(C(O)=O)[CH2:31][CH2:30]1.S(Cl)(Cl)=O.C(NCC)C>>[CH2:30]([N:29]([CH2:34][CH3:33])[C:13]([CH:15]1[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]1)=[O:14])[CH3:31]

Participants

Reactant 4

HCID 8021Diethylamine

HCID 24386Thionyl Chloride

HCID 27369391-Methylpiperidine-4-carboxylic acid

HCID 11610526Lasmiditan

Product 1

HCID 412858N,N-DIETHYL-1-METHYL-PIPERIDINE-4-CARBOXAMIDE

Procedure

The present invention relates to a process for preparing 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide or salt thereof, further comprising the step of: reacting 1-methylpiperidine-4-carboxylic acid with thionyl chloride and diethyl amine to yield N,N-diethyl-1-methylpiperidine-4-carboxamide.

Sources & evidence

ORD record: ord-10810a44372647769ef5b4cf3ebc9bf3
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08697876B2

Reaction notes

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