Hydrochloric Acid → HCID 69005136, compound

HRID 2367020Notes

Reaction equation

HRID 2367020 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:4]=[C:5]([C:9]2[CH2:13][CH:12]([C:14]([N:16]3[CH2:20][CH2:19][C@H:18]([NH:21]C(=O)OC(C)(C)C)[CH2:17]3)=[O:15])[O:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1.[ClH:31]>C(Cl)Cl.O1CCOCC1>[ClH:31].[F:29][C:2]([F:1])([F:30])[C:3]1[CH:4]=[C:5]([C:9]2[CH2:13][CH:12]([C:14]([N:16]3[CH2:20][CH2:19][C@H:18]([NH2:21])[CH2:17]3)=[O:15])[O:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57803349HCID 57803349, compound

Product 1

HCID 69005136HCID 69005136, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of the intermediate of step E in methylene chloride (5 mL) was added 4 M HCl in dioxane (5 mL). After stirred at room temperature for 2 h, the resulting solution was concentrated in vacuo to give the HCl salt (350 mg) of the amine as a white solid. LCMS: (M+H)+ 364.4.

Workup

  1. concentrationthe resulting solution was concentrated in vacuo

Sources & evidence

ORD record
ord-91e3559248554126ad7bdeead9fd30d7
Source dataset
uspto-grants-2014_04
Patent number
US08697870B2

Reaction notes

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