Formic Acid → HCID 66616084, compound

HRID 2367064Notes

Reaction equation

HRID 2367064 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][C:19]([F:23])=[CH:20][CH:21]=3)[C:16]([CH3:25])([CH3:24])[C:15]2=[O:26])[CH2:10][CH2:9]1)C1C=CC=CC=1.C(O)=O>[OH-].[Pd+2].[OH-].C(O)C>[F:23][C:19]1[CH:18]=[C:17]2[C:22](=[CH:21][CH:20]=1)[N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:15](=[O:26])[C:16]2([CH3:25])[CH3:24]

Participants

5

Reactant 2

HCID 284Formic AcidHCID 66616016HCID 66616016, compound

Product 1

HCID 66616084HCID 66616084, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 1-(1-benzylpiperidin-4-yl)-5-fluoro-3,3-dimethylindolin-2-one (171 mg, 0.485 mmol, EXAMPLE 44, Step 3), palladium hydroxide (20 wt % on carbon) (85 mg), formic acid (0.372 mL, 9.7 mmol) and ethanol (20 mL) was stirred at 50° C. for 1 h.

Sources & evidence

ORD record
ord-0eaf48b0deb048ad955d7f3207d9867d
Source dataset
uspto-grants-2014_04
Patent number
US08697877B2

Reaction notes

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