Potassium Acetate → 4-Thiazolecarboxylic acid, 2-[(acetyloxy)methyl]-, ethyl ester

HRID 2367163Notes

Reaction equation

HRID 2367163 reaction equation
Br[CH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1.[C:13]([O-:16])(=[O:15])[CH3:14].[K+]>C(#N)C>[C:13]([O:16][CH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1)(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 11043146Ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate

Product 1

HCID 672815594-Thiazolecarboxylic acid, 2-[(acetyloxy)methyl]-, ethyl ester

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2.7 g (10.80 mmol) of ethyl 2-(bromomethyl)thiazole-4-carboxylate are dissolved in 108 mL of acetonitrile. 2.225 g (22.67 mmol) of potassium acetate are added and the medium is stirred at room temperature for 14 hours.

Sources & evidence

ORD record
ord-56f3e3f6ea094caaae2b3de53619b5e9
Source dataset
uspto-grants-2014_04
Patent number
US08697883B2

Reaction notes

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