Hydrochloric Acid → Hydrochloric Acid

HRID 2367556Notes

Reaction equation

HRID 2367556 reaction equation
[CH:1]1([NH:7][C:8]([C@H:10]2[O:15][CH2:14][C@@H:13]([CH2:16][CH3:17])[N:12](C(OC(C)(C)C)=O)[CH2:11]2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCOCC1.[ClH:31]>>[ClH:31].[CH:1]1([NH:7][C:8]([C@H:10]2[O:15][CH2:14][C@@H:13]([CH2:16][CH3:17])[NH:12][CH2:11]2)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58504507HCID 58504507, compound

Product 2

HCID 313Hydrochloric AcidHCID 51353732HCID 51353732, compound

Procedure

1,1-Dimethylethyl(2S,5R)-2-[(cyclohexylamino)carbonyl]-5-ethyl-4-morpholinecarboxylate (0.2963 g, 0.870 mmol) was taken up in HCl in 1,4-dioxane (4 M, 5 ml, 165 mmol) and stirred at room temperature overnight. The reaction was concentrated to afford a HCl salt of the title compound (0.256 g). LC-MS (ES) m/z=241 [M+H]+.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-eabbc57bec8e403d8d3b6f2f90f47d37
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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