Hydrochloric Acid → Hydrochloric Acid

HRID 2367561Notes

Reaction equation

HRID 2367561 reaction equation
[CH2:1]([C@H:3]1[N:8](C(OC(C)(C)C)=O)[CH2:7][C@@H:6]([C:16]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[O:5][CH2:4]1)[CH3:2].O1CCOCC1.[ClH:32]>>[ClH:32].[CH2:1]([C@H:3]1[NH:8][CH2:7][C@@H:6]([C:16]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[O:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58504456HCID 58504456, compound

Product 2

HCID 313Hydrochloric AcidHCID 58504454HCID 58504454, compound

Procedure

1,1-Dimethylethyl(2S,5R)-5-ethyl-2-{[(phenylmethyl)amino]carbonyl}-4-morpholinecarboxylate (0.551 g, 1.581 mmol) was taken up in HCl in 1,4-dioxane (4 M, 5 mL, 165 mmol) and was stirred at room temperature overnight. The reaction was concentrated to afford a HCl salt of the title compound (0.400 g) as a brown oil. LC-MS (ES) m/z=249 [M+H]+.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-acbcc37749ea47018e20f33bc4305ac0
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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