2-Fluoro-3-methoxy-6-nitrophenol → 1344684-73-6

HRID 2368092Notes

Reaction equation

HRID 2368092 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([N+:10]([O-])=O)[C:3]=1[OH:13]>C(O)C.C1COCC1.[OH-].[Pd+2].[OH-]>[NH2:10][C:4]1[C:3]([OH:13])=[C:2]([F:1])[C:7]([O:8][CH3:9])=[CH:6][CH:5]=1

Participants

5

Reactant 1

HCID 104199412-Fluoro-3-methoxy-6-nitrophenol

Product 1

HCID 575174891344684-73-6Yield 87.3%

Reagents, catalysts & solvents 3

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 2-fluoro-3-methoxy-6-nitrophenol (300 mg) and 5% palladium hydroxide (40 mg) in ethanol (10 mL) and THF (5 mL) was stirred at room temperature for 15 hr under a hydrogen atmosphere (1 atm). The mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (220 mg).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1f7242abf2df429e8ed042634e77de01
Source dataset
uspto-grants-2014_04
Patent number
US08703758B2

Reaction notes

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