1-Methylpiperazine → HCID 12703424, 화합물

HRID 236813노트

반응식

[Cl:1][C:2]1[S:3][CH:4]=[C:5]2[C:11](=O)[NH:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[O:7][C:6]=12.ClC1SC=C2C(Cl)=NC3C=CC=CC=3OC=12.[CH3:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.[C:40]([O-:47])(=[O:46])/[CH:41]=[CH:42]/[C:43]([O-:45])=[O:44]>>[C:40]([OH:47])(=[O:46])/[CH:41]=[CH:42]/[C:43]([OH:45])=[O:44].[Cl:1][C:2]1[S:3][CH:4]=[C:5]2[C:11]([N:37]3[CH2:38][CH2:39][N:34]([CH3:33])[CH2:35][CH2:36]3)=[N:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[O:7][C:6]=12

참가 물질

반응물 4

HCID 531671-Methylpiperazine

HCID 5460307Fumarate

HCID 12581868HCID 12581868, 화합물

HCID 21315972HCID 21315972, 화합물

생성물 1

HCID 12703424HCID 12703424, 화합물

실험 절차

A 4.0 g. portion of 3-chloro-thieno[3,4-b][1,5]benzoxazepin-10(9H)-one is converted to 3,10-dichloro-thieno[3,4-b][1,5]benzoxazepine as described in Example 12. This compound is then reacted with N-methylpiperazine giving the base compound as a foam which is further converted to the fumarate, m.p. 150°-151° C.

출처 및 근거

ORD 기록: ord-19f6ec3b467f48e79255995df4983f35
출처 데이터셋: uspto-grants-1979_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04157444

반응 노트

불러오는 중…