HCID 178467816, compound → HCID 178467817, compound

HRID 2368160Notes

Reaction equation

HRID 2368160 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[C:13]([CH:14]=2)=[N:12][N:11]([C@H:15]2[CH2:20][CH2:19][C@H:18](/[CH:21]=[CH:22]/[C:23](=[O:25])[CH3:24])[CH2:17][CH2:16]2)[CH:10]=3)[CH2:3][CH2:2]1>C(OCC)(=O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[C:13]([CH:14]=2)=[N:12][N:11]([C@H:15]2[CH2:20][CH2:19][C@H:18]([CH2:21][CH2:22][C:23](=[O:25])[CH3:24])[CH2:17][CH2:16]2)[CH:10]=3)[CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 178467816HCID 178467816, compound

Product 1

HCID 178467817HCID 178467817, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of (3E)-4-{trans-4-[6-(cyclopropylmethoxy)-2H-indazol-2-yl]cyclohexyl}but-3-en-2-one (2.85 g), palladium-activated carbon ethylenediamine complex (0.538 g) and ethyl acetate (100 mL) was stirred at room temperature for 15 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (2.75 g).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-11604b866a2a4570b9f441c14b09ff5e
Source dataset
uspto-grants-2014_04
Patent number
US08703758B2

Reaction notes

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