Trifluoroacetic acid → HCID 87288485, compound

HRID 2368201Notes

Reaction equation

HRID 2368201 reaction equation
[CH2:1]([O:3][C:4]([O:6][CH:7]([O:9][C:10](=[O:30])[C@H:11]([CH3:29])[N:12](C12C(C)(C)C1CCC(C)C2=O)OC(C)(C)C)[CH3:8])=[O:5])[CH3:2].[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>C(Cl)Cl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH2:1]([O:3][C:4]([O:6][CH:7]([O:9][C:10](=[O:30])[C@H:11]([CH3:29])[NH2:12])[CH3:8])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131731334HCID 131731334, compound

Product 1

HCID 87288485HCID 87288485, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound from step 1 (12.9 g) is solubilised in 25 ml of CH2Cl2 and 25 ml of trifluoroacetic acid is added at 0° C. The mixture is stirred at ambient temperature for 3 hours. When the reaction is complete, the reaction mixture is evaporated to dryness. The residue is taken up 3 times with cyclohexane and the mixture is re-evaporated to remove the excess TFA. Slightly brown oil, 13.4 g (99%).

Workup

  1. customthe reaction mixture is evaporated to dryness
  2. customthe mixture is re-evaporated
  3. customto remove the excess TFA

Sources & evidence

ORD record
ord-a13504bbbc704e94a8ea15ceb37a72ed
Source dataset
uspto-grants-2014_04
Patent number
US08703747B2

Reaction notes

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