反应详情

温度

75 °C

A mixture of N-cyclopropyl-2-chloro-2-hydroxyimino-acetamide (2 g, 12.3 mmol) and (E)-3-(dimethylamino)-acrylic acid ethyl ester (1.76 ml, 12.3 mmol) in THF (25 ml) was heated at 75° C. for 2 h. The reaction was then cooled to r.t., poured into 100 mL ethyl acetate and extracted with 1 M HCl. The aqueous layers were back-extracted with ethyl acetate. The organic phase was washed with water and brine, dried and evaporated. The product was obtained after purification by silica gel chromatography using a heptane/ethyl acetate gradient as light yellow solid (1.6 g, 58%).

1. temperatureThe reaction was then cooled to r.t.
2. extractionextracted with 1 M HCl
3. extractionThe aqueous layers were back-extracted with ethyl acetate
4. washThe organic phase was washed with water and brine
5. customdried
6. customevaporated
7. customThe product was obtained
8. customafter purification by silica gel chromatography