Hydrochloric Acid → HCID 57513717, compound

HRID 2368411Notes

Reaction equation

HRID 2368411 reaction equation
C([O:5][C:6](=O)[NH:7][C:8]([C:11](=[O:31])[NH:12][C:13]1[S:14][C:15]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:17]=1)([CH3:10])[CH3:9])(C)(C)C.Cl.CCO[C:37]([CH3:39])=O>>[CH:37]1([CH2:39][C:6]([NH:7][C:8]([CH3:10])([CH3:9])[C:11]([NH:12][C:13]2[S:14][C:15]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[C:16]([C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)[N:17]=2)=[O:31])=[O:5])[CH2:19][CH2:18][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 57513707HCID 57513707, compound

Product 1

HCID 57513717HCID 57513717, compound

Procedure

{1-[4-(4-Fluoro-phenyl)-5-morpholin-4-yl-thiazol-2-ylcarbamoyl]-1-methyl-ethyl}-carbamic acid tert-butyl ester was stirred overnight in freshly prepared HCl (g)/EtOAc solution. Evaporation to dryness afforded the desired product as the hydrochloride salt. 1H NMR (400 MHz, DMSO-D6) 1.63 (s, 6H) 2.81-2.89 (m, 4H) 3.70-3.78 (m, 4H) 7.23-7.29 (m, 2H) 8.10-8.16 (m, 2H) 8.62 (s, 3H) 12.46 (s, 1H).

Workup

  1. customEvaporation to dryness

Sources & evidence

ORD record
ord-55978f3e000c4946964c4edc0ba4e06a
Source dataset
uspto-grants-2014_04
Patent number
US08703761B2

Reaction notes

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