Hydrochloric Acid → HCID 57513825, compound

HRID 2368429Notes

Reaction equation

HRID 2368429 reaction equation
C(OC(=O)[NH:7][C:8]([C:11](=[O:31])[NH:12][C:13]1[S:14][C:15]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:17]=1)([CH3:10])[CH3:9])(C)(C)C.Cl>CCOC(C)=O>[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([NH:12][C:13]1[S:14][C:15]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:17]=1)=[O:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57513707HCID 57513707, compound

Product 1

HCID 57513825HCID 57513825, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

{1-[4-(4-Fluoro-phenyl)-5-morpholin-4-yl-thiazol-2-ylcarbamoyl]-1-methyl-ethyl}-carbamic acid tert-butyl ester was stirred overnight in freshly prepared HCl (g)/EtOAc solution. Evaporation to dryness afforded the title compound as the hydrochloride salt. 1H NMR (400 MHz, DMSO-D6) 1.63 (s, 6H) 2.81-2.89 (m, 4H) 3.70-3.78 (m, 4H) 7.23-7.29 (m, 2H) 8.10-8.16 (m, 2H) 8.62 (s, 3H) 12.46 (s, 1H).

Workup

  1. customEvaporation to dryness

Sources & evidence

ORD record
ord-cdf20596af55449c848485c67946d939
Source dataset
uspto-grants-2014_04
Patent number
US08703761B2

Reaction notes

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