反应详情

2-(2-Fluorophenethyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid (45) was prepared in a similar manner as that described for the synthesis of compound 7 using ethyl 2-(2-fluorophenethyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (44) (222 mg, 0.62 mmol), lithium hydroxide (60 mg, 2.5 mmol), THF (1.0 mL), methanol (1.0 mL), and water (2 mL).