反应详情

1-(4-Fluorophenyl)-2-((pyridin-4-ylmethyl)thio)-1H-imidazole-5-carboxylic acid (51) was prepared in a similar manner as that described for the synthesis of compound 11 using ethyl 1-(4-fluorophenyl)-2-(pyridine-4-ylmethyl)thio)-1H-imidazole-5-carboxylate (50) (390 mg, 1.09 mmol), 1N LiOH (5 mL) in THF (5 mL) and MeOH (5 mL).