反应详情

1-(4-Fluorophenyl)-4-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylic acid (59) was prepared in a similar manner as that described for the synthesis of compound 11 using ethyl 1-(4-fluorophenyl)-4-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylate (58) (300 mg, 0.71 mmol), 1N LiOH (5 mL) in THF (5 mL) and MeOH (5 mL).