反应详情

温度

100 °C

5-Acetylpyrimidine (1 g, 8.2 mmol) and N,N-dimethylformamide dimethyl acetal (1.3 g, 11 mmol) were dissolved in 20 mL of isopropanol. The solution was stirred at 100° C. for 24 hours, cooled to room temperature, and concentrated under reduced pressure. Ethyl ether was then added to the residue. After being cooled in an ice bath for a couple of hours, the solid was collected by filtration, rinsed with cold ethyl ether, dried in vacuum to obtain 1 g (59% yield) of the title compound. MS (M+1)=178.0.

1. temperaturecooled to room temperature
2. concentrationconcentrated under reduced pressure
3. additionEthyl ether was then added to the residue
4. temperatureAfter being cooled in an ice bath for a couple of hours
5. filtrationthe solid was collected by filtration
6. washrinsed with cold ethyl ether
7. customdried in vacuum