反应详情

250 mg (1.13 mmol) of 2-amino-6-mercapto-4-(methylthio)pyridine-3,5-dicarbonitrile, 412 mg (1.69 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 378 mg (4.50 mmol) of sodium bicarbonate are combined in 5 ml of DMF and stirred at room temperature for 12 h. A voluminous solid precipitates out, which solid is filtered off using a glass frit, washed three times with water and twice with diethyl ether and dried. This gives a white powder.

1. customA voluminous solid precipitates out, which solid
2. filtrationis filtered off
3. washwashed three times with water
4. dry with materialtwice with diethyl ether and dried
5. customThis gives a white powder