Pyridine → Chloromethyl isopropyl carbonate

Temperature

0 °C

1.32 g of isopropanol was added to 2.63 g of chloromethyl chloroformate, then 20 ml of ethyl ether was added and the mixture solution was cooled to 0° C. The solution of 1.659 g of pyridine in 10 ml of ethyl ether was added into the solution, and the mixture was reacted for 1 hour at that temperature, and then reacted at room temperature for 5 hours. The reaction was stopped, and the filtrate was washed respectively with diluted hydrochloric acid and water once. The organic phase was dried and concentrated to give crude 1-chloromethyl isopropyl carbonate, which was directly used in the next reaction without purification.

1. customthe mixture was reacted for 1 hour at that temperature
2. customreacted at room temperature for 5 hours
3. washthe filtrate was washed respectively with diluted hydrochloric acid and water once
4. customThe organic phase was dried
5. concentrationconcentrated

ORD record

ord-a25190a5f04a462188e46c7667ac5c39

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

USRE044873E1