Hydrochloric Acid → 4-Methyl-2-Pentanol

HRID 2369717Notes

Reaction equation

HRID 2369717 reaction equation
CC(CC)[O-:3].[Al+3].CC(CC)[O-].CC(CC)[O-].[CH2:17]([O:19][C:20](=O)[CH2:21][C:22](=O)C)[CH3:18].[CH3:26][CH:27]([CH3:32])[CH2:28][CH:29]([OH:31])[CH3:30].Cl>CC(C)CC(O)C.C(OCC(O)C)C>[CH3:26][CH:27]([CH3:32])[CH2:28][CH:29]([OH:31])[CH3:30].[CH2:17]([O:19][CH2:20][CH:21]([OH:3])[CH3:22])[CH3:18]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 79104-Methyl-2-PentanolHCID 8868Ethyl AcetoacetateHCID 61289Aluminum sec-butoxide2×

Product 2

HCID 79104-Methyl-2-PentanolHCID 152871-Ethoxy-2-propanol

Reagents, catalysts & solvents 1

HCID 86645796HCID 86645796, compoundSolvent

Procedure

First, 17.2 g of aluminum sec-butoxide (ASBD, manufactured by Kawaken Fine Chemicals Co., Ltd.), 4.56 g of 3-oxobutanoic acid ethyl ester, and 4-methyl-2-pentanol were mixed and stirred to form a uniform solution. After 0.01 M dilute hydrochloric acid was dissolved in a 4-methyl-2-pentanol/1-ethoxy-2-propanol mixed solvent, the resulting solution was slowly added to the aluminum sec-butoxide solution. The mixture was stirred for some time. The solvent was adjusted to finally obtain the mixed solvent of 53 g of 4-methyl-2-pentanol and 23 g of 1-ethoxy-2-propanol. The mixture was further stirred in an oil bath with a temperature of 120° C. for 2 to 3 hours or more, thereby preparing a precursor sol of aluminum oxide. The amounts of 0.01 M dilute hydrochloric acid added were changed stepwise from 0.88 g to 2.02 g to prepare precursor sols 1 to 7 of aluminum oxide.

Workup

  1. customto form a uniform solution
  2. stirringThe mixture was stirred for some time

Sources & evidence

ORD record
ord-bad96d0a76cb40f3b77037e74ed7bb45
Source dataset
uspto-grants-2014_04
Patent number
US08709144B2

Reaction notes

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