Ammonium thiocyanate → HCID 178505564, compound

HRID 236996Notes

Reaction equation

HRID 236996 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=O)=[CH:4][CH:3]=1.[S-:17][C:18]#[N:19].[NH4+:20]>C(O)CC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:19]=[C:18]([SH:17])[NH:20][C:9]=2[C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 15666Ammonium thiocyanateHCID 21314975HCID 21314975, compound

Product 1

HCID 178505564HCID 178505564, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

Alternatively, reaction of 63.4 g (0.27 mole) of 2-(4-fluorophenyl)-2-hydroxy-1-(2-thienyl)ethanone with 29.0 g (0.38 mole) of ammonium thiocyanate in 1-propanol gave 71.6 g of 4-(4-fluorophenyl)-5-(2-thienyl)-1H-2-imidazolethiol, m.p. 275°-277° (Recrystallized from 1-butanol).

Workup

  1. customgave
  2. custom71.6 g of 4-(4-fluorophenyl)-5-(2-thienyl)-1H-2-imidazolethiol, m.p. 275°-277° (Recrystallized from 1-butanol)

Sources & evidence

ORD record
ord-65b63310b8494152a608b7fa6b70d224
Source dataset
uspto-grants-1979_06
Patent number
US04159338

Reaction notes

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