3-Hydroxypiperidine → 1-(4-(Oxazol-2-yl)phenyl)piperidin-3-ol

HRID 2369983Notes

Reaction equation

HRID 2369983 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH:15]([OH:19])[CH2:14]1>>[O:9]1[CH:10]=[CH:11][N:12]=[C:8]1[C:5]1[CH:6]=[CH:7][C:2]([N:13]2[CH2:18][CH2:17][CH2:16][CH:15]([OH:19])[CH2:14]2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 232933-HydroxypiperidineHCID 110750322-(4-Bromophenyl)oxazole

Product 1

HCID 712269401-(4-(Oxazol-2-yl)phenyl)piperidin-3-olYield 45%

Procedure

1-(4-(Oxazol-2-yl)phenyl)piperidin-3-ol (245 mg, 1.00 mmol) was synthesized, in 45% yield, as described in General Procedure B using 2-(4-bromophenyl)oxazole (500 mg, 2.232 mmol) and piperidin-3-ol (451 mg, 4.46 mmol). Anal. Calcd. for C14H16N2O2 m/z 244.2, found: 245.0 (M+H)+.

Sources & evidence

ORD record
ord-603344b271854a86aa52ff01deb160ff
Source dataset
uspto-grants-2014_04
Patent number
US08710049B2

Reaction notes

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