Hydrochloric Acid → HCID 67450266, compound

HRID 2370067Notes

Reaction equation

HRID 2370067 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:26][CH2:27][S:28]([CH3:31])(=[O:30])=[O:29])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:25])[N:12]=2>CCOCC>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:26][CH2:27][S:28]([CH3:31])(=[O:30])=[O:29])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:25])[N:12]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53386373HCID 53386373, compound

Product 1

HCID 67450266HCID 67450266, compoundYield 123.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Add HCl (2.0 M solution in ether) (0.018 g, 0.0005 mol, 1.0 eq) to a solution of 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(2-(methylsulfonyl)ethyl)-9H-purine (0.24 g, 0.0005 mol) in ether (4 mL) at 0° C. and stir for 2 h at room temperature. Filter the precipitate and wash with ether and dry under vacuum to provide the title compound (0.15 g) as white solid. ES/MS m/z 449 (M+1).

Workup

  1. filtrationFilter the precipitate
  2. washwash with ether
  3. customdry under vacuum

Sources & evidence

ORD record
ord-23b384fc1c164b5fa1611656702b60bd
Source dataset
uspto-grants-2014_04
Patent number
US08710063B2

Reaction notes

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