Hydrochloric Acid → HCID 67450266, compound

HRID 2370070Notes

Reaction equation

HRID 2370070 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH2:25][CH2:26][S:27]([CH3:30])(=[O:29])=[O:28])[C:10]2[C:15]([N:16]=1)=[C:14]([N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[N:13]=[C:12]([CH3:24])[N:11]=2.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH2:25][CH2:26][S:27]([CH3:30])(=[O:29])=[O:28])[C:10]2[C:15]([N:16]=1)=[C:14]([N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[N:13]=[C:12]([CH3:24])[N:11]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53386373HCID 53386373, compound

Product 1

HCID 67450266HCID 67450266, compoundYield 173.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Suspend 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(2-methylsulfonylethyl)purine (11.3 g, 25.2 mmol) in ethanol (150 mL) and add 1 N aqueous hydrogen chloride solution (6.29 mL, 25.2 mmol, 1 eq). Allow the mixture to stir overnight and concentrate under reduced pressure. Collect the precipitated solids by filtration, wash with acetone, and dry under vacuum to afford the title compound (10.6 g). ES/MS m/z 449 (M+1).

Workup

  1. concentrationconcentrate under reduced pressure
  2. customCollect the precipitated solids
  3. filtrationby filtration
  4. washwash with acetone
  5. customdry under vacuum

Sources & evidence

ORD record
ord-a6cff83892564ae4ba733b8314cf25d1
Source dataset
uspto-grants-2014_04
Patent number
US08710063B2

Reaction notes

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