Hydrochloric Acid → HCID 67446835, compound

HRID 2370072Notes

Reaction equation

HRID 2370072 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:27][CH2:28][NH2:29])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH3:25])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:26])[N:12]=2>CCOCC>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:27][CH2:28][NH2:29])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH2:23]1)[N:14]=[C:13]([CH3:26])[N:12]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67446836HCID 67446836, compound

Product 1

HCID 67446835HCID 67446835, compoundYield 163.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Add HCl (2.0 M solution in ether) (0.027 g, 0.7 mmol) to a mixture of 2-[8-(2-chlorophenyl)-6-(4-ethylpiperazin-1-yl)-2-methyl-purin-9-yl]ethanamine (0.3 g, 0.7 mmol) in ether (5 mL) at 0° C. and stir for 2 h at room temperature. Collect the precipitate by filtration and wash with ether. Dry under vacuum to give the title compound (0.25 g) as a white solid. ES/MS m/z 400 (M+1).

Workup

  1. customCollect the precipitate
  2. filtrationby filtration
  3. washwash with ether
  4. customDry under vacuum

Sources & evidence

ORD record
ord-979c3bc3e0194c9ba0c7cf6af17fefa3
Source dataset
uspto-grants-2014_04
Patent number
US08710063B2

Reaction notes

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