Hydrochloric Acid → HCID 67449589, compound

HRID 2370075Notes

Reaction equation

HRID 2370075 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:26][CH2:27][NH:28][C:29](=[O:32])[O:30][CH3:31])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:25])[N:12]=2>CCOCC>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:26][CH2:27][NH:28][C:29](=[O:32])[O:30][CH3:31])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:25])[N:12]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 62705988HCID 62705988, compound

Product 1

HCID 67449589HCID 67449589, compoundYield 194.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Add HCl (2.0 M solution in ether) (0.024 g, 0.0006 mol) to a solution of methyl N-[2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethyl]carbamate (0.3 g, 0.0006 mol) in ether (6 mL) at 0° C. and stir for 2 h at room temperature. Filter the precipitate, wash with ether, and dry under vacuum to afford the title compound (0.28 g) as a white solid. ES/MS m/z 444 (M+1).

Workup

  1. filtrationFilter the precipitate
  2. washwash with ether
  3. customdry under vacuum

Sources & evidence

ORD record
ord-374a2f1eb758430d868e4793dbcda11e
Source dataset
uspto-grants-2014_04
Patent number
US08710063B2

Reaction notes

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