HRID237008

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15666

Ammonium isothiocyanate

CH4N2S

HCID20460416

2-Hydroxy-2-phenyl-1-(pyridin-3-yl)ethan-1-one

C13H11NO2

PRODUCTS

生成物

HCID178527827

未命名化合物

收率 44.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1031

1-Propanol

C3H8O

PROCEDURE

实验过程

3-Pyridyl α-hydroxybenzyl ketone (8.15 g; 38.3 mmoles) was reacted with 7.5 g (0.1 mole) of ammonium thiocyanate in 1-propanol heated at reflux to give 4.3 g of 4-phenyl-5-(3-pyridyl)-1H-2-imidazolethiol, m.p. 317°-323° recrystallized from DMF:H2O (2:1).

WORKUP

后处理

temperatureheated
temperatureat reflux