Sodium Bicarbonate → Morphine

HRID 2370089Notes

Reaction equation

HRID 2370089 reaction equation
S(O)(O)(=O)=O.[CH:6]1[C:22]2[CH2:21][C@H:20]3[N:23]([CH2:25][CH2:26][C@@:12]45[C@H:19]3[CH:18]=[CH:17][C@H:15]([OH:16])[C@@H:13]4[O:14][C:10]([C:11]=25)=[C:8]([OH:9])[CH:7]=1)[CH3:24].C([O-])(O)=O.[Na+]>O>[CH:6]1[C:22]2[CH2:21][C@H:20]3[N:23]([CH2:25][CH2:26][C@@:12]45[C@H:19]3[CH:18]=[CH:17][C@H:15]([OH:16])[C@@H:13]4[O:14][C:10]([C:11]=25)=[C:8]([OH:9])[CH:7]=1)[CH3:24]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 546428064-31-3

Product 1

HCID 5288826MorphineYield 81%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 g (2.64 mmol) of morphine sulfate was dissolved in 100 mL of distilled water and then NaHCO3 (3.79 g, 45 mmol) was added. Morphine free base precipitated out. Precipitated morphine free base was then filtered and left to dry overnight in a dessicator under partial vacuum. 0.613 g (81% yield).

Workup

  1. customMorphine free base precipitated out
  2. filtrationPrecipitated morphine free base was then filtered
  3. waitleft
  4. customto dry overnight in a dessicator under partial vacuum

Sources & evidence

ORD record
ord-59fbb916bc7f41908e35fcb808c2a17e
Source dataset
uspto-grants-2014_04
Patent number
US08710069B2

Reaction notes

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