4-Nitrobenzenesulfonyl chloride → 1-[(p-Nitrophenyl)sulfonyl]-4-(o-bromophenyl)piperazine

HRID 237027Notes

Reaction equation

HRID 237027 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(N(CC)CC)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:24]2[CH2:23][CH2:22][N:21]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[Br:14])[CH2:26][CH2:25]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 27571531-(2-Bromophenyl)piperazine

Product 1

HCID 213148281-[(p-Nitrophenyl)sulfonyl]-4-(o-bromophenyl)piperazine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzenesulfonyl chloride, 1-(o-bromophenyl)piperazine and triethylamine are stirred at reflux to give 1-[(p-nitrophenyl)sulfonyl]-4-(o-bromophenyl)piperazine.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-e5c3a5628e8f4dceb6f3a0793f5c121a
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Reaction notes

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