反应详情

2-Chloro-benzooxazol-6-ol (1 eq) and 2-chloro-benzylamine (2 eq) was dissolved in NMP. Using a Personal Chemistry microwave system, the mixture was reacted at 180° C. for six minutes. The crude reaction mixture was diluted with ethyl acetate and washed once with brine and once with 1N HCl, or washed twice with brine, depending on the amine used. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. This material was purified by silica gel column using hexane and ethyl acetate. MH+=275.1.

1. customthe mixture was reacted at 180° C. for six minutes
2. customThe crude reaction mixture
3. washwashed once with brine and once with 1N HCl
4. washwashed twice with brine
5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customThis material was purified by silica gel column