Hydrochloric Acid → HCID 23346179, compound

HRID 237063Notes

Reaction equation

HRID 237063 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][C:7]2[C:8](=[O:15])[NH:9][C:10](SC)=[N:11][CH:12]=2)=[CH:4][CH:3]=1.[Br:18][C:19]1[C:20]([CH2:25][S:26][CH2:27][CH2:28][NH2:29])=[N:21][CH:22]=[CH:23][CH:24]=1.Cl>>[ClH:1].[Br:18][C:19]1[C:20]([CH2:25][S:26][CH2:27][CH2:28][NH:29][C:10]2[NH:9][C:8](=[O:15])[C:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:17][CH:16]=3)=[CH:12][N:11]=2)=[N:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 129459805-(4-Chlorobenzyl)-2-methylthiopyrimid-4-oneHCID 129515272-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine

Product 1

HCID 23346179HCID 23346179, compound

Procedure

5-(4-Chlorobenzyl)-2-methylthio-4-pyrimidone (1.2 g) was reacted with 2-(3-bromo-2-pyridylmethylthio)ethylamine (1.1 g) according to the procedure of Example 2. The reaction mixture was acidified with dilute ethanolic hydrogen chloride, evaporated to dryness and the residue recrystallised from ethanol/water to give 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride, m.p. 215°-218° (decomposes).

Workup

  1. customevaporated to dryness
  2. customthe residue recrystallised from ethanol/water

Sources & evidence

ORD record
ord-74eef8316ff341e6b7fcb4a7c482fbdc
Source dataset
uspto-grants-1979_06
Patent number
US04159329

Reaction notes

Loading…