Trifluoroacetic acid → Trifluoroacetic acid

HRID 2370649Notes

Reaction equation

HRID 2370649 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3([CH2:20][CH2:19]3)[CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]2)=[CH:4][CH:3]=1.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>C(Cl)Cl>[CH2:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([NH2:1])[CH:11]=2)[C:6]2([CH2:20][CH2:19]2)[CH2:7][NH:8]1.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68195399HCID 68195399, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 68194822HCID 68194822, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 7′-amino-1′H-spiro[cyclopropane-1,4′-isoquinoline]-2′(3′H)-carboxylate (0.350 g, 1.276 mmol) in CH2Cl2 (8 ml) was added trifluoroacetic acid (0.983 ml, 12.76 mmol). The reaction was stirred overnight and concentrated to provide the title compound as a trifluoroacetic acid salt.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-9f3373c186c84dd6bc2e4f8fe75777d3
Source dataset
uspto-grants-2014_04
Patent number
US08710065B2

Reaction notes

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