Hydrochloric Acid → HCID 178511689, compound

HRID 2370726Notes

Reaction equation

HRID 2370726 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[C:16](Cl)=[C:17]3[C:22](=[CH:23][CH:24]=2)[CH:21]=[N:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1)(C)(C)C.[ClH:27]>>[Cl:27][C:24]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][N:20]=[CH:21]2)=[CH:16][C:15]=1[O:14][C@H:11]1[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178454060HCID 178454060, compound

Product 1

HCID 178511689HCID 178511689, compound

Procedure

18 mg (0.05 mmol) trans-[4-(5-Chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10) were stirred in 2 M HCl at room temperature. After 2 days, the solvent was removed i. vac. and the residue was purified by preparative HPLC. 8 mg of the title compound could be obtained as trifluoro acetate. Rt=0.69 min (Method #1). Detected mass: 277.2/279.2 (M+H+).

Workup

  1. customthe solvent was removed i
  2. customand the residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-350356b8451c4b1593617b80e183ce0a
Source dataset
uspto-grants-2014_04
Patent number
US08710228B2

Reaction notes

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