反应详情

To a solution of methyl 1-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxylate (0.75 g, 4.43 mmol) in 5 mL DMF at 23° C., were added potassium carbonate (1.8 g, 13.3 mmol) and MeI (1.5 g, 11 mmol). The resulting mixture was stirred overnight and then MeOH (6 mL) was added and the resulting mixture was stirred for 2 h. The volatiles were removed under vacuum, and the resulting residue was dissolved in EtOAc (75 mL), washed with water (2×50 mL), brine (50 mL), dried (MgSO4), and concentrated to give methyl 1-methoxy-6-oxo-1,6-dihydropyridine-3-carboxylate as a brown oil.

1. stirringthe resulting mixture was stirred for 2 h
2. customThe volatiles were removed under vacuum
3. dissolutionthe resulting residue was dissolved in EtOAc (75 mL)
4. washwashed with water (2×50 mL), brine (50 mL)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated