HCID 86612813, compound → HCID 11601466, compound

HRID 2370940Notes

Reaction equation

HRID 2370940 reaction equation
C(OC([NH:8][C:9]1[N:14]=[CH:13][C:12]([CH2:15][C:16]([C:25]2[N:26]=[CH:27][N:28]([CH2:30][C:31]#[CH:32])[CH:29]=2)(C(OC)=O)[C:17]([O:19]C)=[O:18])=[CH:11][CH:10]=1)=O)(C)(C)C>Cl>[NH2:8][C:9]1[N:14]=[CH:13][C:12]([CH2:15][CH:16]([C:25]2[N:26]=[CH:27][N:28]([CH2:30][C:31]#[CH:32])[CH:29]=2)[C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 86612813HCID 86612813, compound

Product 1

HCID 11601466HCID 11601466, compoundYield 86.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 40 mg (0.09 mmol) of the compound from example 31a in 1.4 ml of 50% concentrated hydrochloric acid was heated at 95° C. for 9 h. Freeze-drying after cooling afforded 21 mg of the title compound as bishydrochloride.

Workup

  1. customFreeze-drying
  2. temperatureafter cooling

Sources & evidence

ORD record
ord-514056924e2c4b728d0387353b6ce400
Source dataset
uspto-grants-2014_04
Patent number
US08710232B2

Reaction notes

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