Triethylamine → HCID 86682374, compound

HRID 2371049Notes

Reaction equation

HRID 2371049 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH2:9][CH2:8][CH:7]([CH2:11][OH:12])[C:5]=2[N:6]=1.CCN(CC)CC.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>C1COCC1.O>[CH3:20][S:21]([O:12][CH2:11][CH:7]1[C:5]2[N:6]=[C:2]([NH2:1])[S:3][C:4]=2[CH2:10][CH2:9][CH2:8]1)(=[O:23])=[O:22]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 15516314HCID 15516314, compound

Product 1

HCID 86682374HCID 86682374, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-4-yl)methanol (3.3 mmol) and Et3N (1.4 mL, 10 mmol) in THF (10 mL) was added MsCl (0.3 mL, 3.6 mmol) dropwise at room temperature. The resulting mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with water (200 mL), filtered, and dried to give the crude product, which was used directly in the next step without further purification.

Workup

  1. filtrationfiltered
  2. customdried

Sources & evidence

ORD record
ord-3965c1e5ec244c70b39764af991a5b1d
Source dataset
uspto-grants-2014_04
Patent number
US08710245B2

Reaction notes

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