3-Chloro-4-(trifluoromethyl)aniline → N-[3-chloro-4-(trifluoromethyl)phenyl]-4-[(1-methylpiperidin-3-yl)methyl]piperazine-1-carboxamide
Reaction equation
[C:1](OC(OC(C)(C)C)=O)(OC(C)(C)C)=[O:2].[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[C:19]([Cl:27])[CH:18]=1.[CH3:28][N:29]1[CH2:34][CH2:33][CH2:32][CH:31]([CH2:35][N:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:30]1>C(Cl)(Cl)Cl.CN(C)C1C=CN=CC=1>[Cl:27][C:19]1[CH:18]=[C:17]([NH:16][C:1]([N:39]2[CH2:40][CH2:41][N:36]([CH2:35][CH:31]3[CH2:32][CH2:33][CH2:34][N:29]([CH3:28])[CH2:30]3)[CH2:37][CH2:38]2)=[O:2])[CH:22]=[CH:21][C:20]=1[C:23]([F:24])([F:25])[F:26]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of di-tert-butyl dicarbonate (114.6 mg) in chloroform (2 ml) was added 4-dimethylaminopyridine (6 mg). A solution of 4-amino-2-chlorobenzotrifluoride (98.1 mg) in chloroform (2 ml) was added and the reaction mixture stirred for 20 minutes at room temperature. A solution of 1-[(1-methylpiperidin-3-yl)methyl]piperazine (98.5 mg) in chloroform (2 ml) was added and the resulting solution was stirred at reflux for 18 hours. The reaction mixture was purified by column chromatography on silica gel (20 g) using a gradient of 100% dichloromethane through to 20% methanolic ammonia in dichloromethane to give the title compound (14 mg).
Workup
- stirringthe resulting solution was stirred
- temperatureat reflux for 18 hours
- customThe reaction mixture was purified by column chromatography on silica gel (20 g)
Sources & evidence
- ORD record
- ord-8e0d3d9fba2e49d6a49b26fb7b1a123d
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08710224B2
Reaction notes
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