Trifluoroacetic acid → N-(3,4-dichlorophenyl)-4-pyrrolidin-3-ylpiperazine-1-carboxamide

HRID 2371161ノート

反応式

HRID 2371161 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH:18]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]3)[CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:13][CH2:14][N:15]([CH:18]3[CH2:22][CH2:21][NH:20][CH2:19]3)[CH2:16][CH2:17]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57656740Tert-butyl 3-(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)pyrrolidine-1-carboxylate

生成物 1

HCID 57656838N-(3,4-dichlorophenyl)-4-pyrrolidin-3-ylpiperazine-1-carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-butyl 3-(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)pyrrolidine-1-carboxylate (690 mg, 1.6 mmol) was dissolved in dichloromethane (50 ml) at room temperature. Trifluoroacetic acid (3 ml) was added and the mixture left to stir for 2 hours then concentrated in vacuo.

後処理

  1. waitthe mixture left
  2. concentrationthen concentrated in vacuo

出典と根拠

ORDレコード
ord-f5557d4287ea4f169dd8bccf8ac7c2e9
出典データセット
uspto-grants-2014_04
特許番号
US08710224B2

反応ノート

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