Acetyl chloride → HCID 756919, compound

HRID 2371218Notes

Reaction equation

HRID 2371218 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:21](Cl)(=[O:23])[CH3:22]>O1CCCC1>[C:21]([N:11]1[CH2:12][CH2:13][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]1)(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 759941-Benzylpiperazine

Product 1

HCID 756919HCID 756919, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-benzylpiperazine (1 g) and triethylamine (1.19 mL) in tetrahydrofuran (20 mL) was stirred at room temperature under argon. Acetyl chloride (0.424 mL) was added and the mixture was stirred for 10 minutes. The reaction was filtered and the white solid washed with ether. The filtrate was concentrated at reduced pressure to give the title compound as a colourless oil (1.2 g).

Workup

  1. filtrationThe reaction was filtered
  2. washthe white solid washed with ether
  3. concentrationThe filtrate was concentrated at reduced pressure

Sources & evidence

ORD record
ord-fbc5a1d019a142478a65a0b09e269f99
Source dataset
uspto-grants-2014_04
Patent number
US08710224B2

Reaction notes

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