Ammonia → HCID 14576437, compound

HRID 2371382Notes

Reaction equation

HRID 2371382 reaction equation
Cl[C:2]1[C:7]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[N:6][C:5]([C:13]#[N:14])=[C:4]([C:15]#[N:16])[N:3]=1.[NH3:17].O.Cl>CN(C)C=O>[NH2:17][C:2]1[C:7]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[N:6][C:5]([C:13]#[N:14])=[C:4]([C:15]#[N:16])[N:3]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 962WaterHCID 145764275-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile

Product 1

HCID 14576437HCID 14576437, compoundYield 69.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.0 g (0.008 mol) of 2-chloro-3-tert-butylamino-5,6-dicyanopyrazine was dissolved in 100 ml of dry N,N-dimethylformamide, and ammonia gas was blown into it under stirring at room temperature. Two hours later, the reaction solution was poured into 1 liter of water and neutralized with hydrochloric acid. The precipitated solid was collected by filtration and recrystallized from isobutyl alcohol to obtain 1.2 g of slightly yellow crystals (yield: 69.4%, melting point: at least 250° C.).

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. customrecrystallized from isobutyl alcohol

Sources & evidence

ORD record
ord-a793ef1ffa3745b4b8040b528d5231ed
Source dataset
uspto-grants-1992_03
Patent number
US05093335

Reaction notes

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