Water → HCID 14576454, compound

HRID 2371383Notes

Reaction equation

HRID 2371383 reaction equation
Cl[C:2]1[C:7]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[N:6][C:5]([C:13]#[N:14])=[C:4]([C:15]#[N:16])[N:3]=1.[CH3:17][NH2:18].O>O1CCCC1>[CH3:17][NH:18][C:2]1[C:7]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[N:6][C:5]([C:13]#[N:14])=[C:4]([C:15]#[N:16])[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6329MethylamineHCID 145764275-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile

Product 1

HCID 14576454HCID 14576454, compoundYield 76.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.0 g (0.008 mol) of 2-chloro-3-tert-butylamino-5,6-dicyanopyrazine was dissolved in 50 ml of tetrahydrofuran., and 1.3 g (0.017 mol) of a 40% methylamine aqueous solution was dropwise added thereto at room temperature. The mixture was stirred for 1 hour, and then the reaction solution was poured into 500 ml of water. The precipitated solid was collected by filtration and recrystallized from isobutyl alcohol to obtain 1.4 g of slightly yellow crystals (yield: 76.1%, melting point: at least 250° C.).

Workup

  1. customat room temperature
  2. filtrationThe precipitated solid was collected by filtration
  3. customrecrystallized from isobutyl alcohol

Sources & evidence

ORD record
ord-598504d88c98459b991563f5897495cb
Source dataset
uspto-grants-1992_03
Patent number
US05093335

Reaction notes

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