Methyl iodide → HCID 19907342, compound

HRID 2371532Notes

Reaction equation

HRID 2371532 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:3].C[I:19].[C:20](OCC)(=O)C>CO>[I-:19].[CH3:1][N+:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([CH3:20])[CH3:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 10489839HCID 10489839, compound

Product 1

HCID 19907342HCID 19907342, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 193 mg of N,N-dimethyl-8-phenyloctylamine in 1.5 ml of absolute methanol, were added dropwise 258 μl of methyl iodide, and the mixture was stirred at a room temperature for 6.5 hours. After adding 3 ml of ethyl acetate, the mixture was stirred with ice-cooling for 30 minutes. Resulting crystal was filtered, washed with ethyl acetate, and dried under a reduced pressure to obtain 238 mg of the title compound as a colorless crystal.

Workup

  1. stirringthe mixture was stirred with ice-
  2. temperaturecooling for 30 minutes
  3. customResulting crystal
  4. filtrationwas filtered
  5. washwashed with ethyl acetate
  6. customdried under a reduced pressure

Sources & evidence

ORD record
ord-2dde68144985470fbea2921f860d9441
Source dataset
uspto-grants-1992_03
Patent number
US05093370

Reaction notes

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