反应详情

To a solution of 14.3-7g of 6 chloro-1-hexanol and 10.39 g of dihydropyran in 30 ml of methylene chloride was added 0.95 g of tosic acid monohydrate, and the mixture was stirred at room temperature for 18 hours, poured into 50 ml of a saturated sodium bicarbonate aqueous solution, stirred for 10 minutes and extracted three times with 100 ml of chloroform. The extracts were combined, washed with a saturated sodium bicarbonate aqueous solution and a saturated sodium chloride aqueous solution, dried over magnesium sulfate, concentrated under a reduced pressure and dried in vacuo. The orange-colored oil thus obtained was vacuum-distilled to obtain 17.43 g of 2-(6-chlorohexyloxy)tetrahydropyran as a colorless oil.

1. stirringstirred for 10 minutes
2. extractionextracted three times with 100 ml of chloroform
3. washwashed with a saturated sodium bicarbonate aqueous solution
4. dry with materiala saturated sodium chloride aqueous solution, dried over magnesium sulfate
5. concentrationconcentrated under a reduced pressure
6. customdried in vacuo
7. customThe orange-colored oil thus obtained
8. distillationwas vacuum-distilled