Methyl chloroformate → HCID 54041960, compound

HRID 2371702Notes

Reaction equation

HRID 2371702 reaction equation
[CH2:1]([N:4]1[CH:8]=[CH:7][S:6][C:5]1=[NH:9])[CH:2]=[CH2:3].C(=O)([O-])O.[Na+].O1[CH2:19][CH2:18][CH2:17][CH2:16]1.Cl[C:21]([O:23][CH3:24])=[O:22]>O>[CH2:1]([N:4]1[C:8]2[CH:19]=[CH:18][CH:17]=[CH:16][C:7]=2[S:6][C:5]1=[N:9][C:21]([O:23][CH3:24])=[O:22])[CH:2]=[CH2:3]

Participants

6

Reactant 4

HCID 6586Methyl chloroformateHCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 19906344HCID 19906344, compound

Product 1

HCID 54041960HCID 54041960, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture comprising 3.8 g of 3-allyl-2-iminothiazole, 3.4 g of sodium hydrogencarbonate and 50 ml of tetrahydrofuran was added 1.9 g of methyl chloroformate dropwise at room temperature under stirring. After reacting for two hours, the reaction mixture was poured into approximately 200 ml of water. The crystals precipitated were collected by filtering to thereby obtain 4.5 g of the objective compound.

Workup

  1. customThe crystals precipitated
  2. customwere collected
  3. filtrationby filtering

Sources & evidence

ORD record
ord-7faeb5f677e945a58a8f9f397c4cfeba
Source dataset
uspto-grants-1992_03
Patent number
US05095025

Reaction notes

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